Ashoka seeks a team of entrepreneurial individuals to launch a country-wide "Housing for All" initiative in Egypt. This Egypt-based team, composed of a Program Leader, Program Manager, and Program Associate, will be part of a global team of business social innovators committed to advance profitable solutions to serve low income populations.

Requirements:
- Demonstrated intra/entrepreneurial track record (starting up or transforming business or social ventures) and program management capabilities.
- Strong strategic and operational skills to convert concepts into actual businesses.
- Capacity to effectively communicate with - and engage - various stakeholders ranging from CEOs to social leaders.·
- Passion for social change and belief in the potential of market-based solutions for development.
- Fluency in Arabic required - familiarity with the Egyptian context a plus.
- Respectively over 10, 5 and 2 years of professional experience for the positions of Program Leader,Program Manager and Program Associate.
- Background in financial services or housing a plus.

Positions available immediately. Includes up to 30% travel, mostly in-country. Competitive package for Egyptian citizen sector (commensurate with qualifications and experience).

If you meet the above criteria, please send a resume and a cover letter summarizing your motivation and qualifications for the position to sschmidt@ashoka.org

Responsibilities include:
- Launching program operations in Egypt leveraging Ashoka's community to bring sustainable housing solutions to low-income populations.
- Engaging decision-makers from the business and citizen sectors as well as major investors and the government to pioneer and scale-up Hybrid Value Chain applications.
- Setting up the overall organization that will enable the transactions required for low-income households to improve their living conditions (e.g. disbursement of housing microfinance, delivery of construction materials, complementary services)
- Systematizing and spreading the learning generated by the Egyptian experience in ways that facilitate the replication of the HVC housing model across countries and regions.

Title:

Research Assistant

Short Description:

 The Canada Research Chair in Mechanobiology of the Pediatric Musculoskeletal System is seeking a highly motivated candidate interested to work on multidisciplinary projects combining techniques of mechanical engineering, biomechanics and biology....For more information, please click here.

Please click on the link below to visit the Faculty of Graduate Studies web site for further details concerning eligibility, application forms and procedures, nomination materials required, and the selection process.

http://www.grad.ubc.ca/awards/index.asp?menu=015,000,000,000

If you have any further inquiries regarding the competition, please contact
Joanne Jablkowski, Killam Assistant
Email: joanne.jablkowski@ubc.ca 
Tel: 604-822-9683
 

Title:

Visit this website

Title:

Postdoctoral Fellow Position

Employer:

University of Chicago

Contact info:

Qualifications: Doctoral level degree (or foreign equivalent) in biology or related fields, with training in molecular genetics, developmental biology or both of particular interest. Familiarity with a wide range of methods for molecular biology and bioinformatic analyses is important. Must be comfortable working with mice. Highly-motivated and very conscientious approach is essential. The ability to get along well with others is essential.

Working Conditions: High-complexity genetics research laboratory based in the Department of Human Genetics at the University of Chicago; exposure to hazardous chemicals, corrosive and toxic materials and biohazards.

Mental Demands: Reading, writing, verbal communication and strong organizational skills. Ability to work independently with a high degree of initiative.

Physical Demands: Must be able to see, hear, walk, talk and write. Ability to exert 10-25 pounds of force and work with hands.

Disclaimer: The above statements are intended to describe the general nature and level of the work being performed by people assigned to this job. They are not intended to be an exhaustive list of all responsibilities, duties and skills required of the incumbent.

Forward your CV to schrist@bsd.uchicago.edu

Short Description:

We are looking for a highly motivated individual interested in using cutting edge techniques to solve basic questions regarding mammalian brain development in general and human developmental disorders in particular. A wide variety of projects are ongoing in the adjacent Dobyns and Millen labs at any given time.

Principle Duties and Responsibilities:

I. 90% Research:
-Assist with organizing subject databases and selecting subjects
-Analyze data generated by aCGH
-Physical mapping of copy number alterations identified by visible chromosome rearrangements or by aCGH in patients with brain malformations or related developmental disorders such as autism
-Analysis and ranking of candidate genes and any non-coding conserved sequences in regions of interest, including in silico analysis of gene and genome structure, expression analysis in embryonic mice, and other methods
-Mutation analysis, most often by direct sequencing, and functional analysis of any potentially significant sequence changes in vitro and in vivo
-Design of transgenic and knock-out mouse models, cloning of the constructs, analysis of stem cells and mouse lines
-Analysis of mutant and wild type animals using a variety of methods of developmental biology
-Review results with PI
II. 10% Laboratory Administration:
-Assist with organization and function of the laboratory, including wet lab space and project specific databases

Title:

Postdoctoral Fellow Position

Employer:

Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI

Contact info:

Interested individuals should send their curriculum vitae, a description of their research interests, and the names of three references to:

Philip J. Gage, Ph.D. philgage@umich.edu,  Departments of Ophthalmology & Visual Sciences and Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48105

Short Description:

An NIH-funded postdoctoral position is available immediately to study the roles of cell signaling pathways and transcriptional networks during mammalian eye development. Highly motivated individuals who recently completed or are completing a Ph.D. degree, have a recent first-authored peer-reviewed paper, and have a strong background in molecular and developmental biology are encouraged to apply. The successful candidate will have the opportunity to gain experience and training in molecular biology, transgenic/knockout mouse technology, functional genomics, and cell culture-based assays.

Title:

Postdoctoral Fellow Position

Employer:

The laboratory of John R. Bermingham, Jr., at the McLaughlin Research Institute

Contact info:

The successful applicant will have a solid background in mammalian cell culture and protein biochemistry, and will be fluent in English. The position, either as a non-tenure track Staff Scientist (Ph.D), or a Postdoctoral Scientist, or an experienced Senior Research Assistant (BA/MS), will be filled by an applicant whose background best fits the project's needs. Salary is commensurate with experience. 
Applications, including names and contact information for three to five individuals who may serve as references, should be sent to:
John R. Bermingham, Jr., Ph.D.
McLaughlin Research Institute
1520 23rd Street South
Great Falls, MT 59405

Short Description:

An experienced scientist is sought as an active team member for a research project to identify genetic regulatory pathways that control axon-Schwann cell interactions and Schwann cell development. This position, in the laboratory of John R. Bermingham, Jr., at the McLaughlin Research Institute, is supported by NINDS and private grants. Emphasis will be placed on developing Schwann cell-neuron coculture systems, and on characterizing protein-protein interactions.

Title:

Postdoctoral Fellow Position

Employer:

Albert Einstein College of Medicine, New York

Contact info:

We invite applications from highly motivated and experienced recent PhDs (a maximum of 2-3 years of previous postdoctoral experience) to participate in a newly funded project. The new Postdoc associate can choose between two types of studies: 1) use tumor cell lines and mouse models to identify collaborating oncogene/tumor suppressor pathways in therapy-resistant lymphomas; 2) investigate how B cells integrate various extracellular signals to reprogram their gene expression pattern during plasma cell differentiation. Prior experience in molecular biology and/or cellular immunology, as documented by publication record, is essential. To apply, please send CV with a brief description of research experience and career goals, plus contact information of 3 references.
 Dr. B. Hilda Ye
Associate Professor
Department of Cell Biology
Albert Einstein College of Medicine
1300 Morris Park Avenue
New York, New York 10461
Email: hye@aecom.yu.edu
Web: http://www.aecom.yu.edu/cellbiology/BCL6/

Short Description:

Studies in the Ye laboratory in the Department of Cell Biology (http://www.aecom.yu.edu/cellbiology/) focus on molecular mechanisms that regulate B lymphocyte maturation and lymphoma pathogenesis with an emphasis on interaction between cell signaling and transcription regulation. We use  multidisciplinary approaches and carry out our studies in a highly collaborative and interactive work environment. At the center of our attention is the germinal center reaction, a critical step in T cell-dependent antibody responses through which somatically mutated, high affinity immunoglobulin molecules and B cell memory response are  generated. On the other hand, the unique hyper-proliferative and highly mutagenic cellular environment also increases the risk of malignant transformation of B cells.

Title:

Postdoctoral Fellow Position

Employer:

University of California, San Francisco (UCSF)

Contact info:

Applicants should have a PhD, MD, or foreign equivalent degree and possess a strong background in cell culture, molecular/cell biology and mouse genetics. Basic experience in lipid biochemistry is preferred but not required. This position is for 2-3 years and is funded from an NIH training grant. It is open for new doctoral graduates or for postgraduates, who have had a maximum of 2-3 years of previous postdoctoral experience. 
The applicant should have permanent US resident status or US  citizenship. Salary is commensurate with number of years of experience after doctoral degree and ranges from $36,996 to $51,036 (http://grants.nih.gov/grants/guide/notice-files/not-od-06-026.html)
 
 Please email CV to:
Farid Chehab, Ph.D
University of California, San Francisco
chehabf@labmed2.ucsf.edu
 

Short Description:

A postdoctoral position is available in early January 2008 at the University of California, San Francisco (UCSF) for an individual to investigate intracellular signalling pathways linking sterol metabolism to insulin > sensitivity in stable cell lines and transgenic mice. In addition, the successful applicant will contribute to ongoing projects, aimed at the characterization of obese and diabetic phenotypes in transgenic mouse models.

Title:

Postdoctoral Fellow Position

Employer:

Columbia University Medical Center.

Contact info:

Applicants must have a strong background in several of the following areas: cell/developmental biology, mouse embryology, microarray analysis, RNA in situ hybridization, and immunohistochemistry. US citizens/Permanent Residents with 0-2 years experience are preferred.

Interested candidates, please send: a) CV, b) name of 3 references, and c) a letter describing research experience and interests to: Philip J. Gage,
Ph.D. (philgage@umich.edu), Departments of Ophthalmology & Visual Sciences and Cell & Developmental Biology, University of Michigan

Short Description:

 Talented and highly motivated individual to investigate basic mechanisms by which the coordinated effects of cell signalling pathways and transcriptional networks regulate organogenesis and cell fate determination during development. Genetic, genomic, embryological, cell culture, and biochemical tools are applied to study the mammalian eye as a model system.
 

Title:

Postdoctoral Fellow Positions

Employer:

University of Michigan Medical School

Contact info:

Expertise in developmental and/or cancer biology is essential. To apply, please send a CV, summary of research interests, and three letters of reference to: Michael M. Shen, Ph.D., Departments of Medicine and Genetics & Development, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, 1130 St. Nicholas Ave., Room 217B, New York, NY 10032. E-mail: mshen@columbia.edu

Short Description:

We have recently relocated to Columbia University Medical Center, and are seeking talented and highly motivated post-docs to work in two areas:

1) Cell-type specification and axis patterning in mouse embryogenesis, focusing on stem cell differentiation and TGFβ signaling pathways (Nature 403: 385-389 (2000); Science 298: 1996-1999 (2002); Current Biology 14: 618-624 (2004); Development 132: 5539-5551 (2005); Development 133: 319-329 (2006); Development 134: 1023-1034 (2007)).

2) Prostate development, stem cells, and cancer, using mouse model systems (Genes Dev. 14: 2410-2434 (2000); Cancer Res. 63: 3886-3890 (2003); Dev. Dyn. 228: 767-778 (2003); Dev. Biol. 267: 387-398 (2004); PNAS 103: 144477-14482 (2006); Cancer Res. 67: 6535-6538 (2007)).

Title:

Director for Gene Targeting and Transgenic Facility

Employer:

University of Connecticut Health Center in Farmington, Connecticut

Contact info:

Candidates should apply electronically by submitting a curriculum vita and three letters of reference to Dr. Barbara E. Kream, Chair, Gene Targeting and Transgenic Facility Search Committee at gttfsearch@uchc.edu. UCHC is an equal opportunity employer M/F/v/PwD.

Short Description:

 The successful candidate should hold a doctoral level degree and have demonstrated expertise in the design and production of gene targeting constructs, the culture and manipulation of mouse embryonic stem cells, morula aggregation, pronuclei and blastocyst injection, mouse embryo manipulations, line rederivation and cryopreservation. The candidate should have managerial experience and capabilities with computer databases. The successful candidate will have a faculty appointment in an appropriate basic science department.
 

Title:

Funded NIH Postdoctoral Fellow Positions

Employer:

National Institutes of Health (NIH)

Contact info:

Candidates wishing to be considered for postdoctoral training should  have a Ph.D. and/or M.D. awarded within the past three years. Applications should be sent to bpavan@mail.nih.gov and must include a cover letter, CV including list of publications in peer-reviewed  journals, and the name/contact information of three people who could provide letters of reference

Short Description:

 The laboratory uses genetic, genomic and embryological tools to study neural crest stem cells, examining their contributions to normal mammalian development and discerning how alterations in their development lead to human disease. The research is relevant to a range of human diseases, including pigmentation-associated syndromes, peripheral nervous system disorders and melanoma. Current projects include mutagenesis screens to identify neural crest disease loci, genetic and genomic approaches to dissect mechanisms underlying melanoma metastasis, and genomic approaches to define neural crest stem cell transcriptional networks. The successful candidate will contribute to the design and scope of the specific training project

Title:

Two postdoctoral positions

Employer:

Department of Genetics at the University of North Carolina at Chapel Hill.

Contact info:

Please send curriculum vitae and list of references to Scott Bultman at Scott_Bultman@med.unc.edu

Short Description:

One position is available to study the role of BRG1and SWI/SNF chromatin-remodeling complexes in various aspects of hematopoiesis including globin gene regulation and inflammation. Experience with molecular techniques such as microarrays, real-time PCR, ChIPs, and flow cytometry are preferred.

A second position is available to study the role of diet, gut microflora, and epigenetic events in colorectal cancer using mouse models maintained in a gnotobiotic facility. Experience with culturing and characterizing commensal bacteria or molecular techniques are preferred.

Title:

Three open tenure-track faculty searches within the Intramural Research Program

Employer:

National Human Genome Research Institute NHGRI (www.genome.gov/DIR)

Contact info:

The position is open to United States citizens and permanent residents. The Department of Health and Human Services and the National Institutes of Health are Equal Opportunity Employers and encourage applications from women and minorities. Interested applicants should submit a curriculum vitae and a three-page
description of their proposed research through our online application system, at http://research.nhgri.nih.gov/apply. Each candidate should also arrange to have three letters of recommendation submitted on their behalf. The closing date for these positions is November 16, 2007.

Requirements:

Doctoral-level scientists who have clearly demonstrated their potential as independent investigators and who have formulated a coherent, tractable research plan for their future work. Successful candidates will bring skills and interests to the position that will complement the expertise of the current investigators in the Institute. We are particularly interested in recruiting scientists who can contribute to and benefit from the high level of collegiality we enjoy within the Institute and on the NIH campus as a whole.

Short Description:

The positions are fully funded and include a generous start-up allowance, an ongoing resource commitment of research support and space, laboratory resources, and positions for personnel and trainees. In addition, successful applicants will have access to NHGRI's outstanding core laboratories, as well as the unparalleled resources of the NIH Clinical Center.

Title:

Director or Senior Scientist - Pharmacology - Exton, PA

Employer:

Melior Discovery, Inc

Contact info:

Submit your resume by e-mail to msaporito@meliordiscovery.com. Please include your salary requirements.

Requirements:

Ph.D. in Biological Science is preferred. The job candidate should want to assume management responsibility in coordinating small animal pharmacology studies, drug target discovery efforts and driving discovery molecules to the IND stage. The job requires a multidisciplinary therapeutic area background and the ability to lead a fast-paced research team charged with the responsibility of testing compounds in vivo models of disease, encompassing a variety of therapeutic areas.

Short Description:

Skills/Abilities: Therapeutic area expertise in one or more of the following areas: cardiovascular, inflammation/immunology/allergy, metabolic disorders,neurology, osteoporosis, urogenital, gastrointestinal or dermatology and a background in small animal pharmacology
Responsibilities include, but are not limited to: Managing a group of scientists in in vivo pharmacology studies Communicating results of studies to internal and external group. Coordinating with a Drug Development group in driving drugs to IND stage.

Title:

Post-doctoral Position:  Molecular Genetics of Myelination and Neuronal Differentiation

Employer:

McLaughlin Research Institute

Contact info:

Please send CV and the names and addresses of persons that can be contacted for references to:

John R. Bermingham, Jr.
McLaughlin Research Institute
1520 23^rd Street SouthGreat Falls, MT 95405 USA
Phone: (406) 454-6003
Email: jrbjr@po.mri.montana.edu
http://www.montana.edu/wwwmri/

Requirements:

Requirements are fluency in English, and publications in western, peer-reviewed journals; the successful applicant will have the potential to obtain his/her own funding.

Short Description:

A postdoctoral position is available to study the molecular genetics of peripheral myelination and/or neuronal differentiation in the laboratory of Dr. John R. Bermingham, Jr. at the McLaughlin Research Institute, a private institute that specializes in mouse genetics.

Title:

Post-doctoral Position: Genetic approaches to Parkinson's disease

Employer:

McLaughlin Research Institute

Contact info:

Please send a letter describing your research interests and goals, CV, and names and contact informations for Three referees to:

Deborah Cabin, Ph.D.
McLaughlin Research Institute
1520 23rd St. South
Great Falls, MT 59405
Phone: 406-454-6035
Email: deb@po.mri.montana.edu
http://www.montana.edu/mri/

Requirements:

A background in molecular genetics is desirable, as is experience with mice.

Short Description:

A postdoctoral position is available to study a mouse neurodegenerative disease caused by synuclein or the normal function of  synuclein. Synuclein was the first gene identified as causing a familial form of Parkinson's disease..

Title:

Post-doctoral Position: Small Animal Imaging

Employer:

Children’s Cancer Research Institute (CCRI) at the University of Texas Health Science Center at San Antonio (UTHSCSA).

Contact info:

Applicants should send a cover letter, curriculum vitae and a list of at least three references, including telephone numbers and e-mail addresses, to the following address:

Charles Keller, MD
Assistant Professor,
Department of Cellular & Structural Biology
Children's Cancer Research Institute
The University of Texas Health Science Center
7703 Floyd Curl Drive
San Antonio , TX 78229-3900
Office 210-562-9062
Fax: 210-562-9014
Email: ccrijobs@uthscsa.edu
http://ccri.uthscsa.edu

Requirements:

Candidates from diverse backgrounds are encouraged to apply. An advanced degree in Biomedical Engineering, Biochemistry, Molecular Biology, or Radiology would qualify the candidate for this position.

Short Description:

This mentored position will empower the candidate to develop and analyze complex conditional genetic mouse models of human disease for the purpose of monitoring therapeutic responses. Our laboratory’s main interest is understanding tumor progression and angiogenesis.

Title:

TWO Post-doctoral Positions

Employer:

Department of Medicine, Division of Pulmonary and Critical Care Medicine, at The University of Rochester School of Medicine and Dentistry, New York

Contact info:

Candidates should send their CV, cover letter, statements of current and future research interests (1 page), publication track record (last 4 years) and the names and addresses/e-mails contacts of three academic referees. Please send direct informal inquiries and full applications to:

Dr Marc A. Williams,
Assistant Professor of Medicine and of Environmental Medicine,
Department of Medicine,
Division of Pulmonary and Critical Care Medicine,
University of Rochester School of Medicine and Dentistry,
KMRB Room 2-9609,
601 Elmwood Avenue, Box 692,
Rochester, NY 14642-8692, USA.
Phone (Office): +1 (585) 276-3274
Phone (Lab): +1 (585) 275-4861 [Lab]
FAX: +1 (585) 273-1058
E-mail: marc_williams@urmc.rochester.edu
http://www.urmc.rochester.edu/

Requirements:

Both positions involve a broad range of immunological, cellular and molecular techniques, cells derived from human subjects with different allergic diseases and human and mouse models of pulmonary disease. These include multiparameter flow cytometry, immunofluorescent microscopy, ELISpot assay, ELISA, multiplex cytokine bead array, quantitative real-time PCR and PCR pathway-focused microarray, Western immunoblotting and immunoprecipitation, dendritic cell culture and functional assays such as antigen uptake, siRNA knock-down and neutralization strategies, T cell proliferation and hematopoietic stem cell engineering. Candidates with experience in some or all of these techniques should definitely apply. Excellent communication skills and command of spoken and written English are an absolute must. Salary and benefits will be commensurate with experience, training, publications and interests.

Short Description:

One post-doctoral scientist will be engaged in a project that seeks to elucidate the role of innate immunity in allergic asthma and other pulmonary diseases in the laboratory of Dr Marc A. Williams. The other post-doctoral scientist will be engaged in a project investigating how allergens and related compounds are sensed by the respiratory innate immune system.

Title:

Post-doctoral Position

Employer:

Department of Animal and Dairy Sciences, Mississippi State University.

Contact info:

Erdogan Memili, DVM, Ph.D.
Assistant Professor
Animal Genomics and Proteomics
Department of Animal and Dairy Sciences
Mississippi State University
4025 Wise Center
Mississippi State, MS 39762
Phone: 662-325-2937
Fax: 662-325-8873
E-mail: em149@ads.msstate.edu
http://www.msstate.edu/research/memili

Requirements:

A Ph.D. in genetics, molecular, cellular and developmental biology, biochemistry or related areas is required. Experience in the following areas is preferred: techniques in molecular, cellular, developmental biology, and genetics including real time PCR, molecular cloning, proteomics, DNA microarrays, genomics, cell culture and transfection, RNAi, bioinformatics skills, and familiarity with gamete and embryo
development in mammals. Additional preference includes strong self-motivation, working effectively with minimal supervision, high degree of organizational skills as well as both written and oral communication skills.

Short Description:

A postdoctoral fellowship is available for an animal molecular biologist with strong self motivation to do research in bovine and porcine genomics, and physiological genomics of preimplantation embryonic development.

A postdoctoral position is available to investigate the efficacy of embryonic stem cell reprogramming on somatic nuclei. Current research emphasizes the integration of mouse genetics and optical imaging techniques in the study of mouse embryogenesis and stem cell biology. 
For more information visit http://www.ski.edu/hadjantonakis

We are located at the cultural diversified Southern California, 30 miles east of downtown Los Angeles. We have obtained NIH funding to study a novel mouse model for Inflammatory Bowel Disease (Cancer Res. 64: 962-968, 2004). We have found mouse genetic background has a profound effect on inflammation and cancer susceptibility but not on mutations of a non-expressed cII reporter gene. We are seeking a postdoctoral fellow to join our small but highly interactive research team to investigate the mutation spectrum of the pivotal Apc and p53 tumor suppressor genes. Another aspect of our research focus is to understand the role of antioxidants in prevention of inflammation. A candidate with a strong background in innate immunity can also contribute to this arm of research. Please submit a letter of interest, curriculum vitae, and names and contact information of three references to: Fong-Fong Chu, Ph.D., Associate Professor, City of Hope Medical Center, 1500 East Duarte Road, Duarte, CA, 91010. E-mail: fchu@coh.org
 

Miriam Meisler, Ph. D.
Professor of Human Genetics
4909 Buhl Box 0618
University of Michigan
Ann Arbor, MI 48109-0618
Tel. 734 763 5546; FAX 734 763 9691

Title:

Assistant professor and Lecturer positions

Employer:

The College of Computer and Information Sciences in Al-Kharj (King Saud University - Saudi Arabia).

Letter:

As-salam alykom,

The College of Computer and Information Sciences in Al-Kharj (King Saud University - Saudi Arabia) is seeking applicants for assistant professor and lecturer positions. Qualifications required are PhD or MS in Computer Science/Engineering, respectively.

Interested individuals please send your CVs to:

Dr. Abdul Aziz Al-Mazyad
Dean of College of Computer Science in Al-Kharj
mazyad@ccis.ksu.edu.sa

Best wishes,

Dr. Mostafa Dahshan
Assistant Professor
CCIS
King Saud University

mdahshan@ccis.ksu.edu.sa

Title:

Post-doctoral Positions: Mouse molecular population genetics

Employer:

Institut des Sciences de l'Evolution, (CNRS-Université Montpellier II), Montpellier, France.

Contact info:

The position is for one year with possible extension, depending on starting date and progress of the project. Applicants should send a CV including summary of past research, current interests and motivation for the present project, as well as contact information for three references to:

Dr. Pierre Boursot
Institut des Sciences de l'Evolution
(UM2-CNRS UMR 5554)
Universite Montpellier II
Case Courrier 063
34095 Montpellier cedex 5
France
Phone: +33 (0)4 67 14 46 86
Fax: +33 (0)4 67 14 45 54
Email: Pierre.Boursot@univ-montp2.fr

Requirements:

Candidates should have a strong background in molecular population genetics and/or molecular genetics. Skills in bioinformatics and programming are desirable. Experience of high throughput polymorphism detection methods would also be favorable. Strong motivation, communication skills and commitment are expected.

Short Description:

The project aims at understanding the historical and selective determinants of the differentiation of the house mouse subspecies, leading to partial incompatibility and reproductive isolation. The approach will combine the study of the patterns of coalescence of genes within and among subspecies with that of the patterns of introgression across a hybrid zone between the subspecies, and will take advantage of the growing knowledge of the mouse genome sequence variation and functional genomics.